Endocrine Abstracts

Background: HIV-infected paediatric patients usually show impaired growth. Data reporting abnormalities in GH–IGF–IGFBPs system are scarce and inconclusive.Aim: To analyse blood concentration of the major components of IGF–IGFBPs system in these children and compare them to growth parameters and to cytokines levels.Methods: prepubertal HIV-infected children, aged 8.2±1.7 years, were evaluated every 6 months duri...

The hypoxia, associated to intra-uterine growth restriction, is related to high concentrations of IGFBP1 and unchanged concentrations of IGF1 in animals. Nevertheless, during threatening life events, low IGFI concentrations and high IGFBP1 concentrations was reported. Furthermore, severe hypoxia increased the IGF1R expression of the neuronal growth cones in the ovine fetal brain. No information is available regarding the regulation of the IGF system by the acute hypoxia in hum...